Drug-Induced Arrhythmia
نویسندگان
چکیده
منابع مشابه
Drug-induced arrhythmia: pharmacogenomic prescribing?
Drug-induced Torsades de Pointes is a rare, unpredictable, and life-threatening serious adverse event. It can be caused by both cardiac and non-cardiac drugs and has become a major issue in novel drug development and for the regulatory authorities. This review describes the problem, predisposing factors, and the underlying genetic predisposition as it is understood currently. The future potenti...
متن کاملContemporary Reviews in Cardiovascular Medicine Drug-Induced Arrhythmia
Prolongation of the QTc interval has been associated with proarrhythmia resulting from a potentially fatal form of polymorphic ventricular tachycardia called torsades de pointes (TdP). Genetic forms of the long-QT syndrome (LQTS) associated with high arrhythmic risk have been causally related to mutations in ion channels responsible for the cardiac action potential; genetic factors associated w...
متن کاملSERIOUS ARRHYTHMIA INDUCED BY TERFENADINE-ERYTHROMYCIN INTERACTIONS
Since the introduction of our local manufacturing of terfenadine, we have observed and expressed our concern about a small but increasing number of serious ventricular arrhythmias associated with the use of this non sedating antihistamine. In January 1997 a case of torsade de pointes ventricular tachycardia was detected in a previously healthy woman taking terfenadine with erythromycin. El...
متن کاملScreening Drug-Induced Arrhythmia Events Using Human Induced Pluripotent Stem Cell
Tingyu Gong, Arun Sharma, Paul W. Burridge, Bhagat Patlolla, Andrew S. Lee, Haodi Wu, Enrique G. Navarrete, Ping Liang, Feng Lan, Verónica Sanchez-Freire, Chelsey Simmons, Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays − Screening Drug-Induced Arrhythmia Events Using Human Induced Pluripotent Stem Cell Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2013 American Heart...
متن کاملAconitine-induced cardiac arrhythmia.
Renewed interest in the pharmacological action of aconitine has followed the work of Sherf (1947), Prinzmetal et al. (1950 and 1951), and Brown and Acheson (1952). Its use in experimental medicine produces stimulus formation in the dog's heart with auricular tachycardia and in certain circumstances ventricular tachycardia and fibrillation: it has become a useful tool in the hands of the researc...
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ژورنال
عنوان ژورنال: Circulation
سال: 2010
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.894725